Details

Autor(en) / Beteiligte

• Hentschel, E
• Schütze, K
• Dufek, W

Titel

Recurrence of chronic duodenal ulcer following initial therapy with pirenzepine or cimetidine

Ist Teil von

• Zeitschrift für Gastroenterologie, 1985-01, Vol.23 (1), p.14

Ort / Verlag

Germany

Erscheinungsjahr

1985

Quelle

MEDLINE

Beschreibungen/Notizen

• Recurrence rates of chronic duodenal ulcer after initial therapy with pirenzepine or cimetidine were investigated in a prospective, randomized trial with a total of 80 patients. After 12 weeks of therapy with pirenzepine (50 mg b.i.d) or cimetidine (200 mg t.i.d. + 400 mg nocte) 68,7% and 88,5% respectively were healed (chi 2 = 3,97; p less than 0,05). These patients showed recurrences in 73,6% after pirenzepine and in 84,6% after cimetidine during a six months observation period. This difference is not statistically significant, nor was life table analysis capable to show any difference in the relapse pattern between the two groups.