Details

Autor(en) / Beteiligte

• Cai, W Q
• Mao, K Y
• Jiang, P Y
• Zhou, Y
• Chen, F L
• Li, D

Titel

Correlation between hepatitis B virus infection and adverse pregnancy outcomes-a systematic review and meta-analysis

Ist Teil von

• Zhonghua gan zang bing za zhi, 2024-06, Vol.32 (6), p.532

Ort / Verlag

China

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• To systematically evaluate the effect of hepatitis B virus (HBV) infection on the risk of adverse pregnancy outcomes. We searched PubMed, Embase, Web of Science, and Cochrane databases. Two researchers independently screened the literature, extracted data, and evaluated the quality. Meta-analysis and cumulative meta-analysis were performed using R4.4.1 software. Fixed/random effects models were used to analyze heterogeneous and non-heterogeneous results. Heterogeneous modifiers were identified by subgroup analysis. Funnel plots and Peters' test were used to analyze potential publication bias. A total of 48 studies involving 92 836 HBsAg-positive pregnant women and 7 123 292 HBsAg-negative pregnant women were included. In terms of adverse pregnancy outcomes, HBV infection was significantly correlated with the occurrence of gestational diabetes mellitus [odds ratio ( )=1.34, 95% confidence interval ( ): 1.17-1.53] and intrahepatic cholestasis ( =2.48, 95% : 1.88-3.29), with statistically significant differences