Zhongguo zhongyao zazhi, 2024-04, Vol.49 (8), p.2262
2024
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- Autor(en) / Beteiligte
- Titel
- Effects of epimedium total flavone capsules on post-stroke cognitive impairment in rats
- Ist Teil von
- Zhongguo zhongyao zazhi, 2024-04, Vol.49 (8), p.2262
- Ort / Verlag
- China
- Erscheinungsjahr
- 2024
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To investigate the effect of epimedium total flavone capsules on post-stroke cognitive impairment(PSCI) in rats. The transient middle cerebral artery occlusion(tMCAO) model was constructed on selected rats, and rats with impaired neurological function were randomly divided into the model group, low, middle, and high dose groups of epimedium total flavone capsules, and nimodipine tablet group. The cognitive function of rats was measured after administration. Pathological changes in brain tissue were observed after hematoxylin-eosin staining(HE). Neuronal nuclei(NeuN) and glial fibrillary acidic protein(GFAP) distribution in brain tissue were tested by immunofluorescent staining. The level of amyloid beta 1-42(Aβ_(1-42)), neuron specific enolase(NSE), acetylcholine(ACH), dopamine(DA), 5-hydroxytryptamine(5-HT), norepinephrine(NE), interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), and hypersensitive C-reactive protein(hs-CRP) in rat serum was tested. Moreover, Western blot was utilized to test the expressio
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1001-5302DOI: 10.19540/j.cnki.cjcmm.20240118.104Titel-ID: cdi_pubmed_primary_38812240
- Format
- –
- Schlagworte
- Amyloid beta-Peptides - metabolism, Animals, Capsules, Cognition - drug effects, Cognitive Dysfunction - drug therapy, Cognitive Dysfunction - etiology, Drugs, Chinese Herbal - administration & dosage, Drugs, Chinese Herbal - pharmacology, Epimedium - chemistry, Flavones - administration & dosage, Flavones - chemistry, Flavones - pharmacology, Humans, Interleukin-1beta - genetics, Interleukin-1beta - metabolism, Male, NF-kappa B - genetics, NF-kappa B - metabolism, Rats, Rats, Sprague-Dawley, Stroke - complications, Stroke - drug therapy