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Efficacy and Safety of Radiation Segmentectomy with 90 Y Resin Microspheres for Hepatocellular Carcinoma
Radiology, 2024-05, Vol.311 (2), p.e231386
Sarwar, Ammar
Malik, M Saad
Vo, Nhi H
Tsai, Leo L
Tahir, Muhammad M
Curry, Michael P
Catana, Andreea M
Bullock, Andrea J
Parker, John A
Eckhoff, Devin E
Nasser, Imad A
Weinstein, Jeffrey L
Ahmed, Muneeb
2024
Details
Autor(en) / Beteiligte
Sarwar, Ammar
Malik, M Saad
Vo, Nhi H
Tsai, Leo L
Tahir, Muhammad M
Curry, Michael P
Catana, Andreea M
Bullock, Andrea J
Parker, John A
Eckhoff, Devin E
Nasser, Imad A
Weinstein, Jeffrey L
Ahmed, Muneeb
Titel
Efficacy and Safety of Radiation Segmentectomy with 90 Y Resin Microspheres for Hepatocellular Carcinoma
Ist Teil von
Radiology, 2024-05, Vol.311 (2), p.e231386
Ort / Verlag
United States
Erscheinungsjahr
2024
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Background Limited data are available on radiation segmentectomy (RS) for treatment of hepatocellular carcinoma (HCC) using yttrium 90 ( Y) resin microsphere doses determined by using a single-compartment medical internal radiation dosimetry (MIRD) model. Purpose To evaluate the efficacy and safety of RS treatment of HCC with Y resin microspheres using a single-compartment MIRD model and correlate posttreatment dose with outcomes. Materials and Methods This retrospective single-center study included adult patients with HCC who underwent RS with Y resin microspheres between July 2014 and December 2022. Posttreatment PET/CT and dosimetry were performed. Adverse events were assessed using the Common Terminology Criteria for Adverse Events, version 5.0. Per-lesion and overall response rates (ie, complete response [CR], objective response, disease control, and duration of response) were assessed at imaging using the Modified Response Evaluation Criteria in Solid Tumors, and overall survival (OS) was assessed using Kaplan-Meier analysis. Results Among 67 patients (median age, 69 years [IQR, 63-78 years]; 54 male patients) with HCC, median tumor absorbed dose was 232 Gy (IQR, 163-405 Gy). At 3 months, per-lesion and overall (per-patient) CR was achieved in 47 (70%) and 41 (61%) of 67 patients, respectively. At 6 months ( = 46), per-lesion rates of objective response and disease control were both 94%, and per-patient rates were both 78%. A total of 88% (95% CI: 79 99) and 72% (95% CI: 58, 90) of patients had a per-lesion and overall duration of response of 1 year or greater. At 1 month, a grade 3 clinical adverse event (abdominal pain) occurred in one of 67 (1.5%) patients. Median posttreatment OS was 26 months (95% CI: 20, not reached). Disease progression at 2 years was lower in the group that received 300 Gy or more than in the group that received less than 300 Gy (17% vs 61%; = .047), with no local progression in the former group through the end of follow-up. Conclusion Among patients with HCC who underwent RS with Y resin microspheres, 88% and 72% achieved a per-lesion and overall duration of response of 1 year or greater, respectively, with one grade 3 adverse event. In patients whose tumors received 300 Gy or more according to posttreatment dosimetry, a disease progression benefit was noted. © RSNA, 2024
Sprache
Englisch
Identifikatoren
eISSN: 1527-1315
Titel-ID: cdi_pubmed_primary_38713023
Format
–
Schlagworte
Aged
,
Carcinoma, Hepatocellular - diagnostic imaging
,
Carcinoma, Hepatocellular - radiotherapy
,
Female
,
Humans
,
Liver Neoplasms - diagnostic imaging
,
Liver Neoplasms - radiotherapy
,
Male
,
Microspheres
,
Middle Aged
,
Positron Emission Tomography Computed Tomography - methods
,
Retrospective Studies
,
Treatment Outcome
,
Yttrium Radioisotopes - therapeutic use
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