Details

Autor(en) / Beteiligte

• Li, R
• Wang, X Y
• Ye, Q Y
• Wang, Y Z
• Zhang, X G
• Ge, X T
• Wang, Q T

Titel

A preliminary in vivo and in vitro study of endothelial cell pyroptosis in the periodontal inflammatory environment

Ist Teil von

• Zhonghua kouqiang yixue zazhi, 2024-05, Vol.59 (5), p.486

Ort / Verlag

China

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• To observe whether endothelial cells undergo pyroptosis in the inflammatory periodontal environment by using a model and , providing an experimental basis for indepth understanding of the underlying pathogenesis of periodontitis. According to the classification of periodontal diseases of 2018, gingival tissues were collected from periodontally healthy subjects and patients with stage Ⅲ-Ⅳ, grade C periodontitis, who presented Department of Oral and Maxillofacial Surgery and Department of Periodontology, School of Stomatology, The Fourth Military Medical University from April to May 2022. Immunohistochemical staining was performed to detect the expression level and distribution of gasdermin D (GSDMD), a hallmark protein of cell pyroptosis, in gingival tissues. Periodontitis models were established in each group by ligating the maxillary second molar teeth of three mice for 2 weeks (ligation group). The alveolar bone resorption was determined by micro-CT (mice without ligation treatment were used as the control