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Indigenous populations renowned for apneic diving have comparatively large spleen volumes. It has been proposed that a larger spleen translates to heightened apnea-induced splenic contraction and elevations in circulating hemoglobin mass (Hb
), which, in theory, improves O
carrying and/or CO
/pH buffering capacities. However, the relation between resting spleen volume and apnea- induced increases in Hb
is unknown. Therefore, we tested the hypothesis that resting spleen volume is positively related to apnea-induced increases in total Hb
.
Fourteen healthy adults (six women; 29 ± 5 years) completed a two-minute carbon monoxide rebreathe procedure to measure pre-apneas Hb
and blood volume. Spleen length, width, and thickness were measured pre-and post-five maximal apneas via ultrasound. Spleen volume was calculated via the Pilström equation (test-retest CV:2 ± 2%). Hemoglobin concentration ([Hb]; g/dl) and hematocrit (%) were measured pre- and post-apneas via capillary blood samples. Post-apneas Hb
was estimated as post-apnea [Hb] x pre-apnea blood volume. Data are presented as mean ± SD.
Spleen volume decreased from pre- (247 ± 95 mL) to post- (200 ± 82 mL, p<0.01) apneas. [Hb] (14.6 ± 1.2 vs. 14.9 ± 1.2 g/dL, p<0.01), hematocrit (44 ± 3 vs. 45 ± 3%, p=0.04), and Hb
(1025 ± 322 vs. 1046 ± 339 g, p=0.03) increased from pre- to post-apneas. Pre-apneas spleen volume was unrelated to post-apneas increases in Hb
(r=-0.02, p=0.47). O
(+28 ± 31 mL, p<0.01) and CO
(+31 ± 35 mL, p<0.01) carrying capacities increased post-apneas.
Larger spleen volume is not associated with a greater rise in apneas-induced increases in Hb
in non-apnea-trained healthy adults.