Details

Autor(en) / Beteiligte

• Eid, Ahmad M
• Natsheh, Hiba
• Issa, Linda
• Zoabi, Majdulin
• Amer, Monia
• Mahamid, Effat
• Mousa, Ahmed

Titel

Capsicum annuum Oleoresin Nanoemulgel - Design Characterization and In vitro Investigation of Anticancer and Antimicrobial Activities

Ist Teil von

• Current pharmaceutical design, 2024, Vol.30 (2), p.151

Ort / Verlag

United Arab Emirates

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The use of naturally occurring bioactive materials is getting great attention owing to their safety and environmental properties. Oily compounds, known as oleoresins, are expected to provide an important source for the natural products industry aiming to develop novel treatments for skin conditions. In this work, oleoresin nanoemulgel formulations have been prepared and investigated for their antibacterial and anticancer properties. Several oleoresin nanoemulgel formulations were prepared by incorporating a Carbopol 940 gel in a self-nanoemulsifying nanoemulsion consisting of , tween 80, and span 80. The systems were characterized for particle size, polydispersity index (PDI), zeta potential, and rheology. The antimicrobial and cytotoxic activities of the optimum formulation were evaluated. The selected formulation is composed of 40% tween, 10% span 80, and 40% oleoresin. This formulation produced a stable nanoemulsion with a narrow PDI value of 0.179 ± 0.08 and a droplet size of 104.0 ± 2.6 nm. Results of the antimicrobial studies indicated high potency of the systems against methicillin-resistant (MRSA) (zone of inhibition of 29 ± 1.9 mm), (33 ± 0.9 mm), (30 ± 1.4 mm), and (21 ± 1.5 mm), as compared to the reference antibiotic, ampicillin (18 ± 1.4 mm against ), and antifungal agent, fluconazole (12 ± 0.1 mm against ). Furthermore, cytotoxicity results, expressed as IC values, revealed that the oleoresin and its nanoemulgel had the best effects against the HepG2 cell line (IC value of 79.43 μg/mL for the nanoemulgel) and MCF7 (IC value of 57.54 μg/mL), and the most potent effect was found against 3T3 (IC value of 45.7 μg/m- L). On the other side, the system did not substantially exhibit activity against By-61 and Hela. oleoresin and its nanoemulgel can be considered valuable sources for the discovery of new antibacterial, antifungal, and anticancer compounds in the pharmaceutical industry, especially due to their potent activity against various cancer cell lines as well as bacterial and fungal strains.