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Extranodal Extension at Pretreatment MRI and the Prognostic Value for Patients with Rectal Cancer
Radiology, 2024-03, Vol.310 (3), p.e232605
Li, Qing-Yang
Yang, Ding
Guan, Zhen
Yan, Xin-Yue
Li, Xiao-Ting
Sun, Rui-Jia
Lu, Qiao-Yuan
Zhang, Xiao-Yan
Sun, Ying-Shi
2024
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Li, Qing-Yang
Yang, Ding
Guan, Zhen
Yan, Xin-Yue
Li, Xiao-Ting
Sun, Rui-Jia
Lu, Qiao-Yuan
Zhang, Xiao-Yan
Sun, Ying-Shi
Titel
Extranodal Extension at Pretreatment MRI and the Prognostic Value for Patients with Rectal Cancer
Ist Teil von
Radiology, 2024-03, Vol.310 (3), p.e232605
Ort / Verlag
United States
Erscheinungsjahr
2024
Quelle
MEDLINE
Beschreibungen/Notizen
Background Detection of extranodal extension (ENE) at pathology is a poor prognostic indicator for rectal cancer, but whether ENE can be identified at pretreatment MRI is, to the knowledge of the authors, unknown. Purpose To evaluate the performance of pretreatment MRI in detecting ENE using a matched pathologic reference standard and to assess its prognostic value in patients with rectal cancer. Materials and Methods This single-center study included a prospective development data set consisting of participants with rectal adenocarcinoma who underwent pretreatment MRI and radical surgery (December 2021 to January 2023). MRI characteristics were identified by their association with ENE-positive nodes (χ test and multivariable logistic regression) and the performance of these MRI features was assessed (area under the receiver operating characteristic curve [AUC]). Interobserver agreement was assessed by Cohen κ coefficient. The prognostic value of ENE detected with MRI for predicting 3-year disease-free survival was assessed by Cox regression analysis in a retrospective independent validation cohort of patients with locally advanced rectal cancer (December 2019 to July 2020). Results The development data set included 147 participants (mean age, 62 years ± 11 [SD]; 87 male participants). The retrospective cohort included 110 patients (mean age, 60 years ± 9; 79 male participants). Presence of vessel interruption and fusion (both < .001), heterogeneous internal structure, and the broken-ring and tail signs (odds ratio range, 4.10-23.20; value range, <.001 to .002) were predictors of ENE at MRI, and together achieved an AUC of 0.91 (95% CI: 0.88, 0.93) in detecting ENE. Interobserver agreement was moderate for the presence of vessel interruption and fusion (κ = 0.46 for both) and substantial for others (κ = 0.61-0.67). The presence of ENE at pretreatment MRI was independently associated with worse 3-year disease-free survival (hazard ratio, 3.00; = .02). Conclusion ENE can be detected at pretreatment MRI, and its presence was associated with worse prognosis for patients with rectal cancer. © RSNA, 2024 See also the editorial by Eberhardt in this issue.
Sprache
Englisch
Identifikatoren
ISSN: 0033-8419
eISSN: 1527-1315
DOI: 10.1148/radiol.232605
Titel-ID: cdi_pubmed_primary_38530176
Format
–
Schlagworte
Extranodal Extension
,
Humans
,
Magnetic Resonance Imaging
,
Male
,
Middle Aged
,
Neoplasms, Second Primary
,
Prognosis
,
Prospective Studies
,
Rectal Neoplasms - diagnostic imaging
,
Retrospective Studies
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