Details

Autor(en) / Beteiligte

• Zhang, Qin
• Li, Qiang
• Wang, Jian
• Jiang, Wen-Li
• Hai, Ping
• Jia, Chun-Mei
• Ren, Liu-Yi
• Wu, Xu-Dong
• Kang, Chuan-Zhi
• Yang, Jian
• Gao, Yuan
• Guo, Lan-Ping

Titel

Triterpenoids in Sorbus pohuashanensis suspension cell treated with yeast extract

Ist Teil von

• Zhongguo zhongyao zazhi, 2024-01, Vol.49 (1), p.130

Ort / Verlag

China

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• This study induced biological stress in Sorbus pohuashanensis suspension cell(SPSC) with yeast extract(YE) as a bio-tic elicitor and isolated and identified secondary metabolites of triterpenoids produced under stress conditions. Twenty-six triterpenoids, including fifteen ursane-type triterpenoids(1-15), two 18,19-seco-ursane-type triterpenoids(16-17), four lupine-type triterpenoids(18-21), two cycloartane-type triterpenoids(22-23), and three squalene-type triterpenoids(24-26), were isolated and purified from the methanol extract of SPSC by chromatography on silica gel, MCI, Sephadex LH-20, and MPLC. Their structures were elucidated by spectroscopic analyses. All triterpenoids were isolated from SPSC for the first time and 22-O-acetyltripterygic acid A(1) was identified as a new compound. Selected compounds were evaluated for antifungal, antitumor, and anti-inflammatory activities, and compound 1 showed an inhibitory effect on NO production in LPS-induced RAW264.7 cells.