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Comparison of Clinical Characteristics of JAK2, CALR and Tri-Negative Driving Mutant Type in Patients with Essential Thrombocythemia
Ist Teil von
Zhongguo shi yan xue ye xue za zhi, 2024-02, Vol.32 (1), p.197
Ort / Verlag
China
Erscheinungsjahr
2024
Quelle
MEDLINE
Beschreibungen/Notizen
To investigate the relationship between mutated genes and clinical features in patients with essential thrombocythemia (ET).
The clinical data of 69 patients with ET from October 2018 to March 2022 were retrospectively analyzed. According to driver mutation type, patients were divided into
group,
group and triple-negative group. The sex, age, cardiovascular risk factors, thrombosis, splenomegaly, routine blood test and coagulation status of patients in three groups were analyzed.
Among 69 ET patients, 46 cases were associated with
mutation, 14 cases with
mutation, 8 cases with triple-negative mutation, and one with
gene mutation. There were no significant differences in age and sex among the three groups (
>0.05). The highest thrombotic rate was 26.09% (12/46) in
group, then 12.5% (1/8) in triple-negative group, while no thrombotic events occurred in
group. The incidence of splenomegaly was the highest in
group (34.78%), while no splenomegaly occurred in triple-negative group. The white blood cell (WBC) count