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A personalized biomimetic dual-drug delivery system via controlled release of PTH 1-34 and simvastatin for in situ osteoporotic bone regeneration
Ist Teil von
Frontiers in bioengineering and biotechnology, 2024, Vol.12, p.1355019
Ort / Verlag
Switzerland
Erscheinungsjahr
2024
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Patients with osteoporosis often encounter clinical challenges of poor healing after bone transplantation due to their diminished bone formation capacity. The use of bone substitutes containing bioactive factors that increase the number and differentiation of osteoblasts is a strategy to improve poor bone healing. In this study, we developed an
dual-drug delivery system containing the bone growth factors PTH
and simvastatin to increase the number and differentiation of osteoblasts for osteoporotic bone regeneration. Our system exhibited ideal physical properties similar to those of natural bone and allowed for customizations in shape through a 3D-printed scaffold and GelMA. The composite system regulated the sustained release of PTH
and simvastatin, and exhibited good biocompatibility. Cell studies revealed that the composite system reduced osteoblast death, and promoted expression of osteoblast differentiation markers. Additionally, by radiographic analysis and histological observation, the dual-drug composite system demonstrated promising bone regeneration outcomes in an osteoporotic skull defect model. In summary, this composite delivery system, comprising dual-drug administration, holds considerable potential for bone repair and may serve as a safe and efficacious therapeutic approach for addressing bone defects in patients with osteoporosis.
Sprache
Englisch
Identifikatoren
ISSN: 2296-4185
eISSN: 2296-4185
Titel-ID: cdi_pubmed_primary_38357710
Format
–
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