Details

Autor(en) / Beteiligte

• Ferreira, Ana Filipa
• Azevedo, Maria João
• Morais, Juliana
• Almeida-Coelho, João
• Leite-Moreira, André M
• Lourenço, André P
• Saraiva, Francisca
• Diaz, Sílvia O
• Amador, Ana Filipa
• Sousa, Carla
• Machado, Ana Paula
• Sampaio-Maia, Benedita
• Ramalho, Carla
• Leite-Moreira, Adelino
• Barros, António S
• Falcão-Pires, Inês

Titel

Stretch-induced compliance mechanism in pregnancy-induced cardiac hypertrophy and the impact of cardiovascular risk factors

Ist Teil von

• American journal of physiology. Heart and circulatory physiology, 2024-05, Vol.326 (5), p.H1193-H1203

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Pressure overload-induced hypertrophy compromises cardiac stretch-induced compliance (SIC) after acute volume overload (AVO). We hypothesized that SIC could be enhanced by physiological hypertrophy induced by pregnancy's chronic volume overload. This study evaluated SIC-cardiac adaptation in pregnant women with or without cardiovascular risk (CVR) factors. Thirty-seven women (1st trimester, 1 T) and a separate group of 31 (3rd trimester, 3 T) women [healthy or with CVR factors (obesity and/or hypertension and/or with gestational diabetes)] underwent echocardiography determination of left ventricular end-diastolic volume (LVEDV) and before (T0), immediately after (T1), and 15 min after (T2; SIC) AVO induced by passive leg elevation. Blood samples for NT-proBNP quantification were collected before and after the AVO. Acute leg elevation significantly increased inferior vena cava diameter and stroke volume from T0 to T1 in both 1 T and 3 T, confirming AVO. LVEDV and also increased immediately after AVO (T1) in both 1 T and 3 T. SIC adaptation (T2, 15 min after AVO) significantly decreased in both trimesters, with additional expansion of LVEDV only in the 1 T. NT-pro-BNP increased slightly after AVO but only in the 1 T. CVR factors, but not parity or age, significantly impacted SIC cardiac adaptation. A distinct functional response to SIC was observed between 1 T and 3 T, which was influenced by CVR factors. The LV of 3 T pregnant women was hypertrophied, showing a structural limitation to dilate with AVO, whereas the lower LV filling pressure values suggest increased diastolic compliance. The sudden increase of volume overload triggers an acute myocardial stretch characterized by an immediate rise in contractility by the Frank-Starling mechanism, followed by a progressive increase known as the slow force response. The present study is the first to characterize echocardiographically the stretch-induced compliance (SIC) mechanism in the context of physiological hypertrophy induced by pregnancy. A distinct functional adaptation to SIC was observed between first and third trimesters, which was influenced by cardiovascular risk factors.