Details

Autor(en) / Beteiligte

• Zhu, Xia
• Huang, Ji-Ye
• Dong, Wan-Ying
• Tang, Hao-Di
• Xu, Si
• Wu, Qielan
• Zhang, Huimin
• Cheng, Ping-Kai
• Jin, Yuxin
• Zhu, Meng-Yu
• Zhao, Wan
• Mao, Yu
• Wang, Haitao
• Zhang, Yan
• Wang, Hao
• Tao, Wenjuan
• Tian, Yanghua
• Bai, Li
• Zhang, Zhi

Titel

Somatosensory cortex and central amygdala regulate neuropathic pain-mediated peripheral immune response via vagal projections to the spleen

Ist Teil von

• Nature neuroscience, 2024-03, Vol.27 (3), p.471

Ort / Verlag

United States

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Pain involves neuroimmune crosstalk, but the mechanisms of this remain unclear. Here we showed that the splenic T helper 2 (T 2) immune cell response is differentially regulated in male mice with acute versus chronic neuropathic pain and that acetylcholinergic neurons in the dorsal motor nucleus of the vagus (ACh ) directly innervate the spleen. Combined in vivo recording and immune cell profiling revealed the following two distinct circuits involved in pain-mediated peripheral T 2 immune response: glutamatergic neurons in the primary somatosensory cortex (Glu )→ACh →spleen circuit and GABAergic neurons in the central nucleus of the amygdala (GABA )→ACh →spleen circuit. The acute pain condition elicits increased excitation from Glu neurons to spleen-projecting ACh neurons and increased the proportion of splenic T 2 immune cells. The chronic pain condition increased inhibition from GABA neurons to spleen-projecting ACh neurons and decreased splenic T 2 immune cells. Our study thus demonstrates how the brain encodes pain-state-specific immune responses in the spleen.