Details

Autor(en) / Beteiligte

• Yoon, Hyung-Suk
• Wu, Jie
• Shidal, Chris
• Sun, Yan
• Franke, Adrian A
• Yang, Jae Jeong
• Braithwaite, Dejana
• Courtney, Regina
• Cai, Hui
• Blot, William J
• Shu, Xiao-Ou
• Zheng, Wei
• Cai, Qiuyin

Titel

Associations between Plasma Tocopherols and Lung Cancer Risk: Results from the Southern Community Cohort Study

Ist Teil von

• Cancer epidemiology, biomarkers & prevention, 2024-04, Vol.33 (4), p.480

Ort / Verlag

United States

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Despite the various anticancer activities of tocopherols, little is known about tocopherols associated with lung cancer risk among low-income African Americans (AA) and European Americans (EA) who are disproportionately affected by the disease. We conducted a nested case-control study that included 209 incident lung cancer cases and 406 matched controls within the Southern Community Cohort Study. Using biospecimens collected at cohort enrollment, plasma levels of α-, β/γ-, δ-, and total-tocopherols were measured by high-performance liquid chromatography with photodiode array detection. Conditional logistic regression was used to estimate ORs and 95% confidence intervals (CI) for lung cancer risk after adjusting for potential confounders. Stratified analyses were also conducted. Plasma levels of total-tocopherols were inversely associated with lung cancer risk overall [OR (95% CI) for the highest vs. lowest tertile = 0.51 (0.30-0.90)]. The inverse association remained significant among EAs [0.20 (0.06-0.65)], men [0.43 (0.21-0.90)], current smokers [0.49 (0.26-0.93)], and cases diagnosed within 2 years of blood draw [0.36 (0.15-0.86)], though we did not find a significant risk reduction among AAs [0.75 (0.39-1.45)]. Notably, we found significant interactions between α-tocopherol and race after controlling the FDR to correct for multiple comparisons (Pinteraction = 0.02). Our results indicate that plasma total-tocopherols are inversely associated with lung cancer risk, but the association may differ across specific isomeric forms of tocopherols, race, or other individuals' characteristics. Further large-scale studies are warranted to confirm our findings. Recommendations on tocopherols for lung cancer prevention should take isomers, race, and smoking behaviors into consideration.