Details

Autor(en) / Beteiligte

• Meier, Lukas
• Antillon, Marina
• Burri, Christian
• Chitnis, Nakul
• Endriss, Yvette
• Keiser, Jennifer
• Moore, Sarah
• Müller, Pie
• Penny, Melissa A
• Voss, Till S
• Mäser, Pascal
• Utzinger, Jürg

Titel

Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute

Ist Teil von

• Chimia, 2023-09, Vol.77 (9), p.582

Ort / Verlag

Switzerland

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as a powerful approach to accelerate drug discovery and development processes, often at a fraction of the costs of de novo developments. For 80 years, collaborating within a network of partnerships, the Swiss Tropical and Public Health Institute (Swiss TPH) has been working along a value chain from innovation to validation and application to combat poverty-related diseases. This article presents an overview of selected know-how repurposing initiatives conducted at Swiss TPH with a particular emphasis on the exploration of drug development pathways in the context of neglected tropical diseases and other infectious diseases of poverty, such as schistosomiasis, malaria and human African trypanosomiasis.