Details

Autor(en) / Beteiligte

• Morais, Rui
• Libanio, Diogo
• Dinis Ribeiro, Mario
• Ferreira, Aníbal
• Barreiro, Pedro
• Bourke, Michael J
• Gupta, Sunil
• Amaro, Pedro
• Küttner Magalhães, Ricardo
• Cecinato, Paolo
• Boal Carvalho, Pedro
• Pinho, Rolando
• Rodríguez de Santiago, Enrique
• Sferrazza, Sandro
• Lemmers, Arnaud
• Figueiredo, Mariana
• Pioche, Marhieu
• Gallego, Francisco
• Albéniz, Eduardo
• Ramos Zabala, Felipe
• Uchima, Hugo
• Berr, Frieder
• Wagner, Andrej
• Marques, Margarida
• Pimentel-Nunes, Pedro
• Gonçalves, Margarida
• Mascarenhas, André
• Soares, Elisa Gravito
• Xavier, Sofia
• Faria-Ramos, Isabel
• Sousa-Pinto, Bernardo
• Gullo, Irene
• Carneiro, Fatima
• Macedo, Guilherme
• Santos-Antunes, João

Titel

Predicting residual neoplasia after a non-curative gastric ESD: validation and modification of the eCura system in the Western setting: the W-eCura score

Ist Teil von

• Gut, 2024-01, Vol.73 (1), p.105-117

Ort / Verlag

England: BMJ Publishing Group Ltd and British Society of Gastroenterology

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• ObjectiveTo evaluate the risk factors for lymph node metastasis (LNM) after a non-curative (NC) gastric endoscopic submucosal dissection (ESD) and to validate and eventually refine the eCura scoring system in the Western setting. Also, to assess the rate and risk factors for parietal residual disease.DesignRetrospective multicentre multinational study of prospectively collected registries from 19 Western centres. Patients who had been submitted to surgery or had at least one follow-up endoscopy were included. The eCura system was applied to assess its accuracy in the Western setting, and a modified version was created according to the results (W-eCura score). The discriminative capacities of the eCura and W-eCura scores to predict LNM were assessed and compared.ResultsA total of 314 NC gastric ESDs were analysed (72% high-risk resection (HRR); 28% local-risk resection). Among HRR patients submitted to surgery, 25% had parietal disease and 15% had LNM in the surgical specimen. The risk of LNM was significantly different across the eCura groups (areas under the receiver operating characteristic curve (AUC-ROC) of 0.900 (95% CI 0.852 to 0.949)). The AUC-ROC of the W-eCura for LNM (0.916, 95% CI 0.870 to 0.961; p=0.012) was significantly higher compared with the original eCura. Positive vertical margin, lymphatic invasion and younger age were associated with a higher risk of parietal residual lesion in the surgical specimen.ConclusionThe eCura scoring system may be applied in Western countries to stratify the risk of LNM after a gastric HRR. A new score is proposed that may further decrease the number of unnecessary surgeries.