Details

Autor(en) / Beteiligte

• Zheng, K
• Jin, L
• Shen, F
• Gao, X H
• Zhu, X M
• Yu, G Y
• Hao, L Q
• Lou, Z
• Wang, H
• Yu, E D
• Bai, C G
• Zhang, W

Titel

The impact of extended waiting time on tumor regression after neoadjuvant chemoradiotherapy for locally advanced rectal cancer

Ist Teil von

• Chung-hua wai kʿo tsa chih, 2023-07, Vol.61 (9), p.777

Ort / Verlag

China

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• To investigate the influence of extending the waiting time on tumor regression after neoadjuvant chemoradiology (nCRT) in patients with locally advanced rectal cancer (LARC). Clinicopathological data from 728 LARC patients who completed nCRT treatment at the First Affiliated Hospital, Naval Medical University from January 2012 to December 2021 were collected for retrospective analysis. The primary research endpoint was the sustained complete response (SCR). There were 498 males and 230 females, with an age ( (IQR)) of 58 (15) years (range: 22 to 89 years). Logistic regression models were used to explore whether waiting time was an independent factor affecting SCR. Curve fitting was used to represent the relationship between the cumulative occurrence rate of SCR and the waiting time. The patients were divided into a conventional waiting time group (4 to <12 weeks, =581) and an extended waiting time group (12 to<20 weeks, =147). Comparisons regarding tumor regression, organ preservation, and surgical conditions