Details

Autor(en) / Beteiligte

• Wang, Y H
• Yuan, H G
• Zhang, L Y
• Lin, Y
• Wang, T
• Xu, H
• Zhao, X
• Duan, H W

Titel

Application of mixture analysis methods in association between metals mixture exposure and DNA oxidative damage

Ist Teil von

• Zhōnghuá yùfáng-yīxué zázhì, 2023-07, Vol.57 (7), p.1026

Ort / Verlag

China

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• To study the association between metals mixture exposure and DNA oxidative damage using mixture analysis methods, and to explore the most significant exposure factors that cause DNA oxidative damage. Workers from steel enterprises were recruited in Shandong Province. Urinary metals were measured by using the inductively coupled plasma mass spectrometry method. The level of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was determined by using the ultra-high performance liquid chromatography-mass spectrometry method. Bayesian kernel machine regression (BKMR), elastic net regression and quantile g-computation regression were used to analyze the association between urinary metals and urinary 8-OHdG. A total of 768 subjects aged (36.15±7.40) years old were included in the study. BKMR, elastic net regression and quantile g-computation all revealed an overall positive association between the mixture concentration and increased urinary 8-OHdG. The quantile g-computation results showed that with a 25% increase in metal