Details

Autor(en) / Beteiligte

• Seners, Pierre
• Mlynash, Michael
• Sreekrishnan, Anirudh
• Ter Schiphorst, Adrien
• Arquizan, Caroline
• Costalat, Vincent
• Henon, Hilde
• Bretzner, Martin
• Heit, Jeremy J
• Olivot, Jean-Marc
• Lansberg, Maarten G
• Albers, Gregory W

Titel

Infarct Core Growth During Interhospital Transfer For Thrombectomy Is Faster At Night

Ist Teil von

• Stroke (1970), 2023-08, Vol.54 (8), p.2167

Ort / Verlag

United States

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Preclinical stroke models have recently reported faster infarct growth (IG) when ischemia was induced during daytime. Considering the inverse rest-activity cycles of rodents and humans, faster IG during the nighttime has been hypothesized in humans. We retrospectively evaluated acute ischemic stroke patients with a large vessel occlusion transferred from a primary to 1 of 3 French comprehensive stroke center, with magnetic resonance imaging obtained at both centers before thrombectomy. Interhospital IG rate was calculated as the difference in infarct volumes on the 2 diffusion-weighted imaging, divided by the time elapsed between the 2 magnetic resonance imaging. IG rate was compared between patients transferred during daytime (7:00-22:59) and nighttime (23:00-06:59) in multivariable analysis adjusting for occlusion site, National Institutes of Health Stroke Scale score, infarct topography, and collateral status. Out of the 329 patients screened, 225 patients were included. Interhospital transfer occurred during nighttime in 31 (14%) patients and daytime in 194 (86%). Median interhospital IG was faster when occurring at night (4.3 mL/h; interquartile range, 1.2-9.5) as compared to the day (1.4 mL/h; interquartile range, 0.4-3.5; <0.001). In multivariable analysis, nighttime transfer remained independently associated with IG rate ( <0.05). Interhospital IG appeared faster in patients transferred at night. This has potential implications for the design of neuroprotection trials and acute stroke workflow.