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Human circulating and tissue-resident memory CD8 + T cells
Ist Teil von
Nature immunology, 2023-07, Vol.24 (7), p.1076
Ort / Verlag
United States
Erscheinungsjahr
2023
Quelle
MEDLINE
Beschreibungen/Notizen
Our current knowledge of human memory CD8
T cells is derived largely from studies of the intravascular space. However, emerging data are starting to challenge some of the dogmas based on this work, suggesting that a conceptual revision may be necessary. In this review, we provide a brief history of the field and summarize the biology of circulating and tissue-resident memory CD8
T cells, which are ultimately responsible for effective immune surveillance. We also incorporate recent findings into a biologically integrated model of human memory CD8
T cell differentiation. Finally, we address how future innovative human studies could improve our understanding of anatomically localized CD8
T cells to inform the development of more effective immunotherapies and vaccines, the need for which has been emphasized by the global struggle to contain severe acute respiratory syndrome coronavirus 2.