Details

Autor(en) / Beteiligte

• Gasmi Benahmed, A
• Noor, S
• Menzel, A
• Gasmi, A

Titel

A Boolean Network Approach to Study the Mechanism Associated with Inflammatory Response Induced by Porphyromonas gingivalis

Ist Teil von

• Archives of Razi Institute, 2023-02, Vol.78 (1), p.1

Ort / Verlag

Iran

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Anaerobic is a rod-shaped bacterium and is a primary agent of periodontal inflammation and thus periodontitis. This bacterium disturbs the normal flora of the oral cavity and causes dysbiosis. Databases including Google Scholar Scopus and PubMed were employed to find the evidence by using keywords like ' ,' 'Boolean network,' 'inflammatory response and ,' 'inflammation and . Only articles that reviewed the role of in oral inflammation were selected. promotes and reorganizes host immune systems against normal host flora, which causes a dysbiotic state. A reorganized immune system induces dysbiosis and periodontitis. Specifically, the role of the C5a receptor in the complement system is vital in this mechanism. can change the metabolic pathways of phagocytic cells without impeding inflammation. Toll-like receptor and complement signaling are inverted by , which aids them in overcoming immunological responses. However, they sustain the inflammation process, which promotes dysbiosis. Instead of a subjective approach, a systems perspective is required to comprehend this intricate process. A Boolean network is a system approach that seems to be a better approach to understanding this complicated interaction process of with the immune system and inflammation. In short, attempts to understand the complex process using the Boolean network will ultimately help in the early detection of periodontitis, and immediate treatment can prevent soft tissue destruction and dentition loss.