Details

Autor(en) / Beteiligte

• Gressier, Elise
• Schulte-Schrepping, Jonas
• Petrov, Lev
• Brumhard, Sophia
• Stubbemann, Paula
• Hiller, Anna
• Obermayer, Benedikt
• Spitzer, Jasper
• Kostevc, Tomislav
• Whitney, Paul G
• Bachem, Annabell
• Odainic, Alexandru
• van de Sandt, Carolien
• Nguyen, Thi H O
• Ashhurst, Thomas
• Wilson, Kayla
• Oates, Clare V L
• Gearing, Linden J
• Meischel, Tina
• Hochheiser, Katharina
• Greyer, Marie
• Clarke, Michele
• Kreutzenbeck, Maike
• Gabriel, Sarah S
• Kastenmüller, Wolfgang
• Kurts, Christian
• Londrigan, Sarah L
• Kallies, Axel
• Kedzierska, Katherine
• Hertzog, Paul J
• Latz, Eicke
• Chen, Yu-Chen E
• Radford, Kristen J
• Chopin, Michael
• Schroeder, Jan
• Kurth, Florian
• Gebhardt, Thomas
• Sander, Leif E
• Sawitzki, Birgit
• Schultze, Joachim L
• Schmidt, Susanne V
• Bedoui, Sammy

Titel

CD4 + T cell calibration of antigen-presenting cells optimizes antiviral CD8 + T cell immunity

Ist Teil von

• Nature immunology, 2023-06, Vol.24 (6), p.979-990

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Antiviral CD8 T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interferon-α/interferon-β (IFNα/β)-induced transcriptional adaptations that endow APCs with the capacity to rapidly activate the transcriptional regulators p65, IRF1 and FOS after CD4 T cell-mediated CD40 stimulation. While these responses operate through broadly used signaling components, they induce a unique set of co-stimulatory molecules and soluble mediators that cannot be elicited by IFNα/β or CD40 alone. These responses are critical for the acquisition of antiviral CD8 T cell effector function, and their activity in APCs from individuals infected with severe acute respiratory syndrome coronavirus 2 correlates with milder disease. These observations uncover a sequential integration process whereby APCs rely on CD4 T cells to select the innate circuits that guide antiviral CD8 T cell responses.