Details

Autor(en) / Beteiligte

• Fernandes, Michelle
• Krebs, Nancy F
• Westcott, Jamie
• Tshefu, Antoinette
• Lokangaka, Adrien
• Bauserman, Melissa
• Garcés, Ana L
• Figueroa, Lester
• Saleem, Sarah
• Aziz, Sumera A
• Goldenberg, Robert L
• Goudar, Shivaprasad S
• Dhaded, Sangappa M
• Derman, Richard J
• Kemp, Jennifer F
• Koso-Thomas, Marion
• Sridhar, Amaanti
• M McClure, Elizabeth
• Hambidge, K Michael

Titel

Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the 'Women First' maternal preconception nutrition randomised controlled trial

Ist Teil von

• Archives of disease in childhood, 2023-08, Vol.108 (8), p.622-631

Ort / Verlag

England

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Maternal nutrition in preconception and early pregnancy influences fetal growth. Evidence for effects of prenatal maternal nutrition on early child development (ECD) in low-income and middle-income countries is limited. To examine impact of maternal nutrition supplementation initiated prior to or during pregnancy on ECD, and to examine potential association of postnatal growth with ECD domains. Secondary analysis regarding the offspring of participants of a maternal multicountry, individually randomised trial. Rural Democratic Republic of the Congo, Guatemala, India and Pakistan. 667 offspring of Women First trial participants, aged 24 months. Maternal lipid-based nutrient supplement initiated preconceptionally (arm 1, n=217), 12 weeks gestation (arm 2, n=230) or not (arm 3, n=220); intervention stopped at delivery. The INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) cognitive, language, gross motor, fine motor, positive and negative behaviour scores; visual acuity and contrast sensitivity scores and auditory evoked response potentials (ERP). Anthropometric z-scores, family care indicators (FCI) and sociodemographic variables were examined as covariates. No significant differences were detected among the intervention arms for any INTER-NDA scores across domains, vision scores or ERP potentials. After adjusting for covariates, length-for-age z-score at 24 months (LAZ ), socio-economic status, maternal education and FCI significantly predicted vision and INTER-NDA scores (R =0.11-0.38, p<0.01). Prenatal maternal nutrition supplementation was not associated with any neurodevelopmental outcomes at age 2 years. Maternal education, family environment and LAZ predicted ECD. Interventions addressing multiple components of the nurturing care model may offer greatest impact on children's developmental potential. NCT01883193.