Details

Autor(en) / Beteiligte

• Si, Jiyeon
• Vázquez-Castellanos, Jorge F
• Gregory, Ann C
• Decommer, Lindsey
• Rymenans, Leen
• Proost, Sebastian
• Centelles Lodeiro, Javier
• Weger, Martin
• Notdurfter, Marlene
• Leitner, Christoph
• Santer, Peter
• Rungger, Gregorio
• Willeit, Johann
• Willeit, Peter
• Pechlaner, Raimund
• Grabherr, Felix
• Kiechl, Stefan
• Tilg, Herbert
• Raes, Jeroen

Titel

Long-term life history predicts current gut microbiome in a population-based cohort study

Ist Teil von

• Nature aging, 2022-10, Vol.2 (10), p.885

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Extensive scientific and clinical microbiome studies have explored contemporary variation and dynamics of the gut microbiome in human health and disease , yet the role of long-term life history effects has been underinvestigated. Here, we analyzed the current, quantitative microbiome composition in the older adult Bruneck Study cohort (Italians, Bruneck, n = 304 (male, 154; female, 150); age 65-98 years) with extensive clinical, demographic, lifestyle and nutritional data collected over the past 26 years . Multivariate analysis of historical variables indicated that medication history, historical physical activity, past dietary habits and specific past laboratory blood parameters explain a significant fraction of current quantitative microbiome variation in older adults, enlarging the explanatory power of contemporary covariates by 33.4%. Prediction of current enterotype by a combination of past and contemporary host variables revealed good levels of predictability (area under the curve (AUC), 0.78-0.83), with Prevotella and dysbiotic Bacteroides 2 being the best predicted enterotypes. These findings demonstrate long-term life history effects on the microbiota and provide insights into lifestyle variables and their role in maintaining a healthy gut microbiota in later life.