Zhongguo shi yan xue ye xue za zhi, 2023-04, Vol.31 (2), p.562
2023
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Details
- Autor(en) / Beteiligte
- Titel
- Factors Influencing and Adverse Reactions of Voriconazole Clearance in Patients with Hematological Diseases
- Ist Teil von
- Zhongguo shi yan xue ye xue za zhi, 2023-04, Vol.31 (2), p.562
- Ort / Verlag
- China
- Erscheinungsjahr
- 2023
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To monitor the changes of voriconazole minimum concentration(C ) in patients with hematological diseases, and evaluate the factors influencing and adverse reactions of voriconazole clearance in patients with hematological diseases, so as to provide a theoretical basis for reasonable clinical use of voriconazole. 136 patients with hematological diseases who used voriconazole in Wuhan NO.1 Hospital from May 2018 to December 2019 were selected. The correlation between C-reactive protein, albumin, creatinine and voriconazole C were analyzed, and the changes of voriconazole C after glucocorticoid treatment was also detected. In addition, stratified analysis was used to explore the adverse events of voriconazole. Among 136 patients, 77 were male (56.62%) and 59 were female (43.38%). There were positive correlations between voriconazole C and C-reactive protein and creatinine levels (r=0.277, r=0.208), while voriconazole C was negatively correlated with albumin level (r=-2.673). Voriconazole C in patients treated wi
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1009-2137DOI: 10.19746/j.cnki.issn.1009-2137.2023.02.036Titel-ID: cdi_pubmed_primary_37096534