Details

Autor(en) / Beteiligte

• Zhu, Xiaolei
• Sakamoto, Shinji
• Ishii, Chiharu
• Smith, Matthew D
• Ito, Koki
• Obayashi, Mizuho
• Unger, Lisa
• Hasegawa, Yuto
• Kurokawa, Shunya
• Kishimoto, Taishiro
• Li, Hui
• Hatano, Shinya
• Wang, Tza-Huei
• Yoshikai, Yasunobu
• Kano, Shin-Ichi
• Fukuda, Shinji
• Sanada, Kenji
• Calabresi, Peter A
• Kamiya, Atsushi

Titel

Dectin-1 signaling on colonic γδ T cells promotes psychosocial stress responses

Ist Teil von

• Nature immunology, 2023-04, Vol.24 (4), p.625-636

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The intestinal immune system interacts with commensal microbiota to maintain gut homeostasis. Furthermore, stress alters the microbiome composition, leading to impaired brain function; yet how the intestinal immune system mediates these effects remains elusive. Here we report that colonic γδ T cells modulate behavioral vulnerability to chronic social stress via dectin-1 signaling. We show that reduction in specific Lactobacillus species, which are involved in T cell differentiation to protect the host immune system, contributes to stress-induced social-avoidance behavior, consistent with our observations in patients with depression. Stress-susceptible behaviors derive from increased differentiation in colonic interleukin (IL)-17-producing γδ T cells (γδ17 T cells) and their meningeal accumulation. These stress-susceptible cellular and behavioral phenotypes are causally mediated by dectin-1, an innate immune receptor expressed in γδ T cells. Our results highlight the previously unrecognized role of intestinal γδ17 T cells in the modulation of psychological stress responses and the importance of dectin-1 as a potential therapeutic target for the treatment of stress-induced behaviors.