Details

Autor(en) / Beteiligte

• Xie, L
• Yang, C
• Jiang, M
• Qiu, Y Q
• Cai, R
• Hu, L L
• Jiang, Y X
• Wang, L
• Chen, Q C
• Wu, S
• Shi, X L
• Hu, Q H
• Li, Y H

Titel

Genomic epidemiology of Vibrio parahaemolyticus from acute diarrheal patients in Shenzhen City from 2013 to 2021

Ist Teil von

• Zhōnghuá yùfáng-yīxué zázhì, 2023-03, Vol.57 (3), p.386

Ort / Verlag

China

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• To characterize the prevalence and genomic epidemiology of from acute diarrheal patients in Shenzhen City from 2013 to 2021. Based on the Shenzhen Infectious Diarrhea Surveillance System, acute diarrheal patients were actively monitored in sentinel hospitals from 2013 to 2021. Whole-genome sequencing (WGS) of isolates was performed, and the genomic population structure, serotypes, virulence genes and multilocus sequence typing were analyzed. Outbreak clusters from 2019 to 2021 were explored based on single-nucleotide polymorphism analysis. A total of 48 623 acute diarrhea cases were monitored in 15 sentinel hospitals from 2013 to 2021, and 1 135 strains were isolated, with a positive isolation rate of 2.3%. Qualified whole-genome sequencing data of 852 isolates were obtained. Eighty-nine serotypes, 21 known ST types and 5 new ST types were identified by sequence analysis, and 93.2% of strains were detected with toxin profile of 8 clonal groups (CGs) were captured, with CG3 as the absolute predominance, follow