Details

Autor(en) / Beteiligte

• Barateau, Véronique
• Peyrot, Loïc
• Saade, Carla
• Pozzetto, Bruno
• Brengel-Pesce, Karen
• Elsensohn, Mad-Hélénie
• Allatif, Omran
• Guibert, Nicolas
• Compagnon, Christelle
• Mariano, Natacha
• Chaix, Julie
• Djebali, Sophia
• Fassier, Jean-Baptiste
• Lina, Bruno
• Lefsihane, Katia
• Espi, Maxime
• Thaunat, Olivier
• Marvel, Jacqueline
• Rosa-Calatrava, Manuel
• Pizzorno, Andres
• Maucort-Boulch, Delphine
• Henaff, Laetitia
• Saadatian-Elahi, Mitra
• Vanhems, Philippe
• Paul, Stéphane
• Walzer, Thierry
• Trouillet-Assant, Sophie
• Defrance, Thierry

Titel

Prior SARS-CoV-2 infection enhances and reshapes spike protein-specific memory induced by vaccination

Ist Teil von

• Science translational medicine, 2023-03, Vol.15 (687), p.eade0550

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The diversity of vaccination modalities and infection history are both variables that have an impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more accurate knowledge of how these parameters imprint on immune memory, we conducted a long-term follow-up of SARS-CoV-2 spike protein-specific immune memory in unvaccinated and vaccinated COVID-19 convalescent individuals as well as in infection-naïve vaccinated individuals. Here, we report that individuals from the convalescent vaccinated (hybrid immunity) group have the highest concentrations of spike protein-specific antibodies at 6 months after vaccination. As compared with infection-naïve vaccinated individuals, they also display increased frequencies of an atypical mucosa-targeted memory B cell subset. These individuals also exhibited enhanced T 1 polarization of their SARS-CoV-2 spike protein-specific follicular T helper cell pool. Together, our data suggest that prior SARS-CoV-2 infection increases the titers of SARS-CoV-2 spike protein-specific antibody responses elicited by subsequent vaccination and induces modifications in the composition of the spike protein-specific memory B cell pool that are compatible with enhanced functional protection at mucosal sites.