Details

Autor(en) / Beteiligte

• Hsu, Alice J
• Lee, Carlton K K
• McAteer, John
• Zhang, Sean X
• Tamma, Pranita D

Titel

Boosting of Voriconazole Levels With Omeprazole, A CYP450 2C19 Inhibitor

Ist Teil von

• The Pediatric infectious disease journal, 2023-06, Vol.42 (6), p.485

Ort / Verlag

United States

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Children metabolize voriconazole faster than adults and require higher weight-based doses and more frequent administration to achieve therapeutic troughs. We report a case of a 4-year-old girl with disseminated fusariosis with persistently undetectable voriconazole troughs. Omeprazole was added as a CYP2C19-inhibitor to increase voriconazole concentrations. This case highlights the role of omeprazole for voriconazole boosting in a child.