Details

Autor(en) / Beteiligte

• Chamani, Sajjad
• Mobasheri, Leila
• Zerehpoosh, Shadi
• Naghizadeh, Ali
• McCloskey, Alice P
• Rizzo, Manfredi
• Jamialahmadi, Tannaz
• Sahebkar, Amirhossein

Titel

The Effect of Statins on the Differentiation and Function of Central Nervous System Cells

Ist Teil von

• Current medicinal chemistry, 2024-01, Vol.31 (11), p.1348

Ort / Verlag

United Arab Emirates

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• Statins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS), and Alzheimer's disease (AD), has received increasing attention in recent years, both within the scientific community and in the media. This review aims to provide an updated discussion on the effects of statins on the differentiation and function of various nervous system cells, including neurons and glial cells. Additionally, the mechanisms of action and how different types of statins enter the CNS will be discussed.