Details

Autor(en) / Beteiligte

• Muri, Jonathan
• Cecchinato, Valentina
• Cavalli, Andrea
• Shanbhag, Akanksha A
• Matkovic, Milos
• Biggiogero, Maira
• Maida, Pier Andrea
• Moritz, Jacques
• Toscano, Chiara
• Ghovehoud, Elaheh
• Furlan, Raffaello
• Barbic, Franca
• Voza, Antonio
• De Nadai, Guendalina
• Cervia, Carlo
• Zurbuchen, Yves
• Taeschler, Patrick
• Murray, Lilly A
• Danelon-Sargenti, Gabriela
• Moro, Simone
• Gong, Tao
• Piffaretti, Pietro
• Bianchini, Filippo
• Crivelli, Virginia
• Podešvová, Lucie
• Pedotti, Mattia
• Jarrossay, David
• Sgrignani, Jacopo
• Thelen, Sylvia
• Uhr, Mario
• Bernasconi, Enos
• Rauch, Andri
• Manzo, Antonio
• Ciurea, Adrian
• Rocchi, Marco B L
• Varani, Luca
• Moser, Bernhard
• Bottazzi, Barbara
• Thelen, Marcus
• Fallon, Brian A
• Boyman, Onur
• Mantovani, Alberto
• Garzoni, Christian
• Franzetti-Pellanda, Alessandra
• Uguccioni, Mariagrazia
• Robbiani, Davide F

Titel

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Ist Teil von

• Nature immunology, 2023-04, Vol.24 (4), p.604

Ort / Verlag

United States

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. Here we discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome and negatively correlated with the development of long COVID at 1 yr post-infection. Chemokine antibodies were also present in HIV-1 infection and autoimmune disorders, but they targeted different chemokines compared with COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bound to the chemokine N-loop impaired cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential.