Details

Autor(en) / Beteiligte

• Khitri, Mohamed-Yacine
• Bartoli, Alessandra
• Maalouf, Georgina
• Deroux, Alban
• Salvarani, Carlo
• Emmi, Giacomo
• Karadag, Omer
• Espinosa, Gerard
• Leclercq, Mathilde
• Simonini, Gabriele
• Vautier, Mathieu
• Cacoub, Patrice
• Saadoun, David

Titel

Tocilizumab in Behçet Disease: A Multicenter Study of 30 Patients

Ist Teil von

• Journal of rheumatology, 2023-07, Vol.50 (7), p.916-923

Ort / Verlag

Canada

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate tocilizumab (TCZ) efficacy in patients with refractory Behçet disease (BD). This is a multicenter study of 30 patients fulfilling the international criteria for BD and treated with TCZ at different European referral centers. The clinical response was evaluated at 6 months from TCZ initiation. Ninety percent of patients with BD were refractory or intolerant to anti-tumor necrosis factor (anti-TNF) agents. Overall, TCZ was effective in 25 (83%) patients with BD of whom 18 (60%) and 7 (23%) were complete and partial responders, respectively. The complete response was 67%, 60%, and 42% in patients with uveitis (18/30), neurological manifestations (5/30), and mucocutaneous and/or articular (7/30) manifestations, respectively. TCZ had a significant steroid-sparing effect allowing patients to decrease their median daily prednisone dose from 20 (IQR 10-40) mg/day to 9 (IQR 5-13) mg at 6 months ( < 0.001). The number of patients with BD needing concomitant disease-modifying antirheumatic drug therapy fell from 7 (23%) to 4 (13%) at 6 months. Mild to moderate side effects were observed in 6 (20%) patients, and 3 (10%) presented with serious adverse events (pneumonia, intestinal perforation, and septicemia) requiring therapy discontinuation in 2 cases. TCZ seems to be an effective alternative to anti-TNF agents in treating BD-related uveitis and neurological manifestations.