Zhēncì yánjiū, 2023-02, Vol.48 (2), p.158
2023
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- Autor(en) / Beteiligte
- Titel
- Effect of electroacupuncture on Notch/NF-κB signaling pathway in colonic mucosa of mice with ulcerative colitis
- Ist Teil von
- Zhēncì yánjiū, 2023-02, Vol.48 (2), p.158
- Ort / Verlag
- China
- Erscheinungsjahr
- 2023
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- To observe the protective effect of electroacupuncture (EA) on the intestinal mucosal barrier and its relationship with the Notch/NF-κB signaling pathway in mice with ulcerative colitis (UC), so as to explore its mechanism of treating UC. Male C57BL/6J mice were randomized into control, model and EA groups, with 6 mice in each group. The UC model was established by giving the mice with 2% Dextran Sulfate Sodium (DSS) for 7 days. EA (2 Hz/15 Hz, 0.2 mA) was applied at bilateral "Zusanli" (ST36) for 30 min, once a day for 7 days. The disease activity indexes ［DAI=(body weight index score+stool score+bleeding score)/3; 0-4 points］ of mice were calculated. The morphological changes of colonic tissues of mice in each group were observed by HE staining, and serum contents of TNF-α and IL-6 were detected by ELISA. Claudin-1 protein expression in colon tissue was detected by immunofluorescence, while the protein expression levels of Muc-2, Notch-1, MMP-9 in colon tissue were detected by immunohistochemistry. The real
- Sprache
- Chinesisch
- Identifikatoren
- ISSN: 1000-0607DOI: 10.13702/j.1000-0607.20211284Titel-ID: cdi_pubmed_primary_36858412