Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors
Ist Teil von
RSC advances, 2023-01, Vol.13 (5), p.2756-2767
Ort / Verlag
England: Royal Society of Chemistry
Erscheinungsjahr
2023
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
A Schiff base ligand HL, (
E
)-2-((adamantan-1-ylimino)methyl)-6-allylphenol, was synthesized by condensation of amantadine with 3-allyl-2-hydroxybenzaldehyde, followed by the synthesis of its Zn(
ii
), Co(
ii
), Cr(
iii
), and VO(
iv
) complexes under reflux conditions. The synthesized compounds were comprehensively elucidated by using different spectroscopic and analytical techniques: UV-Vis,
1
H and
13
C-NMR, FT-IR, ESI-MS, thermal, and single-crystal XRD analysis. The chemical composition of the synthesized compounds was also verified by molar conductance and elemental analysis. An octahedral geometry for Cr(
iii
) and Co(
ii
) complexes, tetrahedral for Zn(
ii
) complex, and square pyramidal geometry have been proposed for VO(
iv
) complexes. The antidiabetic activities of the synthesized compounds were also evaluated by performing
in vitro
α-amylase and α-glucosidase inhibition studies. The Co(
ii
) complex exhibited the highest α-glucosidase inhibitory activity, whereas oxovanadium(
iv
) and zinc(
ii
) complexes were also found to be effective against α-amylase. In alkaline phosphatase (ALP) inhibition studies, the HL was found to be inactive, while the complexes showed remarkable enzyme inhibition in the following order: VO > Zn > Co, in a concentration-dependent manner.
Metal complex formation of a Schiff base ligand with Zn(
ii
), Co(
ii
), Cr(
iii
), and VO(
iv
). α-Amylase and α-glucosidase inhibition by these metal complexes.