Details

Autor(en) / Beteiligte

• Ajaz, Aliya
• Shaheen, Muhammad Ashraf
• Ahmed, Maqsood
• Munawar, Khurram Shahzad
• Siddique, Abu Bakar
• Karim, Abdul
• Ahmad, Nazir
• Rehman, Muhammad Fayyaz ur

Titel

Synthesis of an amantadine-based novel Schiff base and its transition metal complexes as potential ALP, α-amylase, and α-glucosidase inhibitors

Ist Teil von

• RSC advances, 2023-01, Vol.13 (5), p.2756-2767

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• A Schiff base ligand HL, ( E )-2-((adamantan-1-ylimino)methyl)-6-allylphenol, was synthesized by condensation of amantadine with 3-allyl-2-hydroxybenzaldehyde, followed by the synthesis of its Zn( ii ), Co( ii ), Cr( iii ), and VO( iv ) complexes under reflux conditions. The synthesized compounds were comprehensively elucidated by using different spectroscopic and analytical techniques: UV-Vis, 1 H and 13 C-NMR, FT-IR, ESI-MS, thermal, and single-crystal XRD analysis. The chemical composition of the synthesized compounds was also verified by molar conductance and elemental analysis. An octahedral geometry for Cr( iii ) and Co( ii ) complexes, tetrahedral for Zn( ii ) complex, and square pyramidal geometry have been proposed for VO( iv ) complexes. The antidiabetic activities of the synthesized compounds were also evaluated by performing in vitro α-amylase and α-glucosidase inhibition studies. The Co( ii ) complex exhibited the highest α-glucosidase inhibitory activity, whereas oxovanadium( iv ) and zinc( ii ) complexes were also found to be effective against α-amylase. In alkaline phosphatase (ALP) inhibition studies, the HL was found to be inactive, while the complexes showed remarkable enzyme inhibition in the following order: VO > Zn > Co, in a concentration-dependent manner. Metal complex formation of a Schiff base ligand with Zn( ii ), Co( ii ), Cr( iii ), and VO( iv ). α-Amylase and α-glucosidase inhibition by these metal complexes.