Details

Autor(en) / Beteiligte

• Pan, Zheng-Yin
• Liang, Bin-Fa
• Zhi, Yun-Shi
• Yao, Da-Hong
• Li, Chen-Yang
• Wu, Hai-Qiang
• He, Liang

Titel

Near-infrared AIE-active phosphorescent iridium() complex for mitochondria-targeted photodynamic therapy

Ist Teil von

• Dalton transactions : an international journal of inorganic chemistry, 2023-01, Vol.52 (5), p.1291-13

Ort / Verlag

England: Royal Society of Chemistry

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Mitochondria-targeted photodynamic therapy (PDT) has recently been recognized as a promising strategy for effective cancer treatment. In this work, a mitochondria-targeted near-infrared (NIR) aggregation-induced emission (AIE)-active phosphorescent Ir( iii ) complex ( Ir1 ) is reported with highly favourable mitochondria-targeted bioimaging and cancer PDT properties. Complex Ir1 has strong absorption in the visible light region (∼500 nm) and can effectively produce singlet oxygen ( 1 O 2 ) under green light (525 nm) irradiation. It preferentially accumulates in the mitochondria of human breast cancer MDA-MB-231 cells as revealed by colocalization analysis. Complex Ir1 displays high phototoxicity toward human breast cancer MDA-MB-231 cells and mouse breast cancer 4T1 cells. Complex Ir1 induces reactive oxygen species (ROS) production, mitochondrial dysfunction, and endoplasmic reticulum (ER) stress in MDA-MB-231 cells upon photoirradiation, leading to apoptotic cell death. The favorable PDT performance of Ir1 in vivo has been further demonstrated in tumour-bearing mice. Together, the results suggest that Ir1 is a promising photosensitizer for mitochondria-targeted imaging and cancer phototherapy. A near-infrared Ir( iii ) complex with aggregation-induced emission (AIE) properties exhibits potent photodynamic anticancer activity in vitro and in vivo upon 525 nm light irradiation.