Details

Autor(en) / Beteiligte

• Ni, Xue-Bing
• Cui, Xiao-Ming
• Liu, Jin-Yue
• Ye, Run-Ze
• Wu, Yu-Qian
• Jiang, Jia-Fu
• Sun, Yi
• Wang, Qian
• Shum, Marcus Ho-Hin
• Chang, Qiao-Cheng
• Zhao, Lin
• Han, Xiao-Hu
• Ma, Ke
• Shen, Shi-Jing
• Zhang, Ming-Zhu
• Guo, Wen-Bin
• Zhu, Jin-Guo
• Zhan, Lin
• Li, Liang-Jing
• Ding, Shu-Jun
• Zhu, Dai-Yun
• Zhang, Jie
• Xia, Luo-Yuan
• Oong, Xiang-Yong
• Ruan, Xiang-Dong
• Shao, Hong-Ze
• Que, Teng-Cheng
• Liu, Guang-Yuan
• Du, Chun-Hong
• Huang, En-Jiong
• Wang, Xin
• Du, Li-Feng
• Wang, Chong-Cai
• Shi, Wen-Qiang
• Pan, Yu-Sheng
• Zhou, Yu-Hao
• Qu, Jiang-Li
• Ma, Jiang
• Gong, Cai-Wei
• Chen, Qi-Qing
• Qin, Qian
• Lam, Tommy Tsan-Yuk
• Jia, Na
• Cao, Wu-Chun

Titel

Metavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes

Ist Teil von

• Nature microbiology, 2023-01, Vol.8 (1), p.162

Ort / Verlag

England

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcriptomes of 31 different tick species in the Ixodidae and Argasidae families from across mainland China, and identified 724 RNA viruses with distinctive virome compositions among genera. A total of 1,801 assembled and complete or nearly complete viral genomes revealed an extensive diversity of genome architectures of tick-associated viruses, highlighting ticks as a reservoir of RNA viruses. We examined the phylogenies of different virus families to investigate virome evolution and found that the most diverse tick-associated viruses are positive-strand RNA virus families that demonstrate more ancient divergence than other arboviruses. Tick-specific viruses are often associated with only a few tick species, whereas virus clades that can infect vertebrates are found in a wider range of tick species. We hypothesize that tick viruses can exhibit both 'specialist' and 'generalist' evolutionary trends. We hope that our virome dataset will enable much-needed research on vertebrate-pathogenic tick-associated viruses.