Details

Autor(en) / Beteiligte

• El Ghazzi, Nathan
• Italiano, Antoine
• Bay, Jacques-Olivier
• Dougé, Aurore

Titel

CAR-T cells development in solid tumors

Ist Teil von

• Bulletin du cancer, 2023-01, Vol.110 (1), p.32

Ort / Verlag

France

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• CAR-T cells have produced very promising results in the field of onco-hematology and have been rapidly approved for marketing in France for several years now. In solid tumors, current results are more disappointing. Indeed, many hurdles come in the way. Tumor vascularization, the strongly immunosuppressive microenvironment, the loss of the target antigen as well as T cell exhaustion are part of the explanation of those results. Hence many researchers are working to develop strategies to counteract these resistance mechanisms. Arming CAR-T cells with BiTEs, with immune checkpoint inhibitors or with interleukins seem to be effective ways to improve antitumor efficacy. Other strategies including vaccines association or local delivery of the CAR-T cells look very promising. Many Phase I studies are investigating these new strategies and are expected to improve the previous results obtained to date in this area.