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Reduced urinary kallikrein activity in rats developing spontaneous hypertension
Ist Teil von
American journal of physiology. Renal physiology, 1987-06, Vol.252 (6), p.964-F969
Ort / Verlag
United States
Erscheinungsjahr
1987
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
J. L. Ader, T. Tran-Van and F. Praddaude
Urinary kallikrein activity, intake, and excretion of sodium and water were
measured in metabolic balance studies on spontaneously hypertensive rats
(SHR) of the Okamoto-Aoki strain and normotensive Wistar-Kyoto rats (WKY)
on a normal sodium diet from 4 through 15 wk of age. Urinary excretion of
active and total kallikrein was significantly lower in SHR at all ages
examined and represented a stable percentage of the values in age-matched
WKY throughout development, on the average 69.5 and 67.4%, respectively.
SHR exhibited a lower urinary excretion of sodium and water than WKY, a
higher cumulative sodium balance at all ages studied, and a higher
cumulative water balance only at ages 7 and 8 wk. The slopes of the
regression lines correlating urinary kallikrein to systolic arterial
pressure and to urinary excretion and cumulative balance of sodium and
water were always significantly less in SHR than in WKY. The results of the
present study indicate that SHR developing hypertension exhibit a
precocious and stable abnormality in renal excretion of kallikrein
activity.