Details

Autor(en) / Beteiligte

• George, Peter M
• Reed, Anna
• Desai, Sujal R
• Devaraj, Anand
• Faiez, Tasnim Shahridan
• Laverty, Sarah
• Kanwal, Amama
• Esneau, Camille
• Liu, Michael K C
• Kamal, Faisal
• Man, William D-C
• Kaul, Sundeep
• Singh, Suveer
• Lamb, Georgia
• Faizi, Fatima K
• Schuliga, Michael
• Read, Jane
• Burgoyne, Thomas
• Pinto, Andreia L
• Micallef, Jake
• Bauwens, Emilie
• Candiracci, Julie
• Bougoussa, Mhammed
• Herzog, Marielle
• Raman, Lavanya
• Ahmetaj-Shala, Blerina
• Turville, Stuart
• Aggarwal, Anupriya
• Farne, Hugo A
• Dalla Pria, Alessia
• Aswani, Andrew D
• Patella, Francesca
• Borek, Weronika E
• Mitchell, Jane A
• Bartlett, Nathan W
• Dokal, Arran
• Xu, Xiao-Ning
• Kelleher, Peter
• Shah, Anand
• Singanayagam, Aran

Titel

A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae

Ist Teil von

• Science translational medicine, 2022-11, Vol.14 (671), p.eabo5795

Ort / Verlag

United States

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications.