Details

Autor(en) / Beteiligte

• Agarwal, Aniruddha
• Corvi, Federico
• Kumar Menia, Nitin
• Aggarwal, Kanika
• Erckens, Roel J.
• Berendschot, Tos T.J.M.
• Webers, Carroll A.B.
• Invernizzi, Alessandro
• Gupta, Vishali
• Sadda, SriniVas

Titel

Choriocapillaris Flow Deficit in Tubercular Serpiginous-Like Choroiditis with and without Paradoxical Worsening

Ist Teil von

• Ocular immunology and inflammation, 2022-11, Vol.ahead-of-print (ahead-of-print), p.1-7

Ort / Verlag

England: Taylor & Francis

Erscheinungsjahr

2022

Link zum Volltext

Beschreibungen/Notizen

• The aim is to analyze automated quantification of choriocapillaris flow deficit (CCFD) on swept-source (SS)-optical coherence tomography angiography (OCTA) in tubercular serpiginous-like choroiditis (TBSLC). In this prospective study, automated CCFD calculations were performed on SS-OCTA and compared with CCFD areas on indocyanine green angiography (ICGA). Patients were divided into two groups based on the occurrence of paradoxical worsening (PW). Twenty-nine eyes (29 subjects; 18 males; mean age: 33±12 years) were included. The mean CCFD at baseline was 34.9 ± 4.3% on OCTA in eyes without PW and 35.4 ± 5.0% on SS-OCTA with PW (p = .77). At 4 and 12 weeks, CCFD on SS-OCTA improved to 30.6 ± 3.9% and 28.0 ± 4.2% (p < .001) without PW, respectively, and increased to 42.9 ± 4.4% and 48.8 ± 4.1% (p < .001) with PW, respectively. The SS-OCTA CCFD correlated well with ICGA (r = 0.48; p < .001). Automated quantitative serial assessment of CCFD on SS-OCTA can serve as a useful biomarker of disease activity in eyes with TBSLC.