Details

Autor(en) / Beteiligte

• Weiss, K
• Sousa, C V
• Knechtle, B

Titel

Autoimmune hepatitis in monozygotic twins - a case report

Ist Teil von

• European review for medical and pharmacological sciences, 2022-10, Vol.26 (20), p.7533

Ort / Verlag

Italy

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Autoimmune hepatitis is a chronic liver disease caused by a dysfunctional immune system. It is widely believed that autoimmune hepatitis accumulates in families. We found that autoimmune hepatitis does accumulate in monozygotic twins. We present middle-aged monozygotic female twins developing autoimmune hepatitis consecutively within two years. Both twins had developed Graves' disease and were treated with carbimazole before the onset of autoimmune hepatitis. Both were cigarette smokers. The twins were treated with budesonide and azathioprine, which normalised liver parameters. This case report supports the hypothesis that a genetic factor might be of great importance in the aetiology of autoimmune hepatitis.