Details

Autor(en) / Beteiligte

• Larrosa-García, María
• Garcia-Garcia, Sonia
• Louro, Javier
• Sánchez-Montalvá, Adrián
• Sampol Sirvent, Julia
• Augustín Recio, Salvador
• Guillén Del Castillo, Alfredo
• Riera-Arnau, Judit
• Gorgas, Maria Queralt
• Miarons, Marta

Titel

Use of chronic medications and risk of death due to COVID-19 in hospitalised patients

Ist Teil von

• European journal of hospital pharmacy. Science and practice, 2024-05, Vol.31 (3), p.247

Ort / Verlag

England

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To evaluate the potential association between chronic exposure to medication and death related to COVID-19. This is a retrospective cross-sectional study that included all patients hospitalised due to COVID-19 from 11 March to 4 June 2020 in our centre. Chronic patient medication was classified by the Anatomical Therapeutic Chemical (ATC) classification; demographic and clinical data were analysed. Multivariate logistic regression models were used to estimate the adjusted odds ratios (aOR) of death for each drug exposure; each aOR represents an independent model adjusted by clinical factors related to COVID-19 mortality. The study included 978 patients with a mean (SD) age of 64.5 (17.7) years who were predominantly male (531, 54.3%). Of all 978 patients, 182 (18.61%) died during the follow-up of the study. The most common Charlson Comorbidity Index (CCI) was 0, 4.2% were smokers, 16.7% were obese, 47.4% had hypertension, and 19.4% were diabetic. Most patients (70.8%) were prescribed at least one treatment, 32.5% used >5 treatments, and 8.6% >10. Our data suggest that COVID-19 hospitalised patients taking trimethoprim and analogues, leukotriene receptor antagonists, calcineurin inhibitors, aldosterone antagonists, selective immunosuppressants, propulsives, insulins and analogues, and benzodiazepine derivatives have a higher risk of death. This study investigated the association between chronic exposure to drugs and the risk of death in COVID-19 patients. Our results have shed some light on the impact of chronic drug exposure on the risk of severe COVID-19; however, further research is needed to increase the understanding about its relevance.