Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...

Details

Autor(en) / Beteiligte
Titel
Adult-born dentate granule cells promote hippocampal population sparsity
Ist Teil von
  • Nature neuroscience, 2022-11, Vol.25 (11), p.1481-1491
Ort / Verlag
United States
Erscheinungsjahr
2022
Quelle
MEDLINE
Beschreibungen/Notizen
  • The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly, the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan, but their contribution to downstream firing dynamics remains unclear. Here, we show that abDGCs promote sparser hippocampal population spiking during mnemonic processing of novel stimuli. By combining triple-(DG-CA3-CA1) ensemble recordings and optogenetic interventions in behaving mice, we show that abDGCs constitute a subset of high-firing-rate neurons with enhanced activity responses to novelty and strong modulation by theta oscillations. Selectively activating abDGCs in their 4-7-week post-birth period increases sparsity of hippocampal population patterns, whereas suppressing abDGCs reduces this sparsity, increases principal cell firing rates and impairs novel object recognition with reduced dimensionality of the network firing structure, without affecting single-neuron spatial representations. We propose that adult-born granule cells transiently support sparser hippocampal population activity structure for higher-dimensional responses relevant to effective mnemonic information processing.
Sprache
Englisch
Identifikatoren
ISSN: 1097-6256
eISSN: 1546-1726
DOI: 10.1038/s41593-022-01176-5
Titel-ID: cdi_pubmed_primary_36216999

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX