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Current pharmaceutical biotechnology, 2023-01, Vol.24 (8), p.1018-1034
Erscheinungsjahr
2023
Beschreibungen/Notizen
Colorectal cancer is a type of gut cancer originating either from the rectum or colon. Genetic
and environmental factors, such as the gut microbiome, play pivotal roles in colorectal cancer
incidence rates. Therefore, we aimed to review the risk factors of CRC comprising gut bacteriomes
and their intra-interactions with each other in the context of CRC development. Gut microbiota alteration,
especially bacteriome alteration as the dominant player, seems to be the common feature
amongst all risk factors. Although it is not quite obvious whether these alterations are the causes or
the consequences of the tumorigenesis risk factors, they are common and almost universal among
CRC-affected individuals. In addition, bacterial genotoxicity, biofilm formation, oxidative stress,
bacterial metabolome, and dysbiosis are assessed in CRC development. The present study suggests
that gut microbial alterations could be the key intermediate, as a cause or a consequence, between
most risk factors of CRC and the way they promote or contribute to CRC development.