Details

Autor(en) / Beteiligte

• Mou, Y K
• Ren, C
• Li, Y M
• Yu, G H
• Zheng, G B
• Song, H
• Lu, C X
• Tian, R X
• Song, X C

Titel

Correlation analysis of clock genes and MEN2 medullary thyroid carcinoma

Ist Teil von

• Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery, 2022-09, Vol.57 (9), p.1079

Ort / Verlag

China

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• To investigate the correlation between and genes and MEN2 medullary thyroid carcinoma (MTC). Thirteen cases with MEN2 MTC and thirteen cases with non-MEN2 MTC were selected who were treated in the Yantai Yuhuangding Hospital between January 2013 and September 2021. Clinical indicators such as blood calcitonin level, tumor diameter and metastatic lymph node of patients were collected. The expression differences of CLOCK and BMAL1 between MEN2 MTC and para-carcinoma tissue as well as between MEN2 MTC and non-MEN2 MTC were detected by immunohistochemistry and qPCR. The correlation between lymph node metastasis and CLOCK or BMAL1 expression was analyzed. Protein-protein interaction (PPI) network analysis combined with qPCR and correlation analysis was used to explore the expression regulation relationship between and circadian clock genes. The rhythm disorder of MEN2 cells was verified by lipopolysaccharide cell stimulation experiment after dexamethasone rhythm synchronization. MEN2 MTC exhibited typical gene mut