Details

Autor(en) / Beteiligte

• Lin, Z J
• Zha, J
• Yi, S H
• Li, Z F
• Ping, L Y
• He, X H
• Yu, H F
• Zheng, Z
• Xu, W
• Chen, F L
• Xie, Y
• Chen, B Y
• Zhang, H L
• Wang, L
• Ding, K Y
• Li, W Y
• Yang, H Y
• Zhao, W L
• Qiu, L G
• Li, Z M
• Song, Y Q
• Xu, B

Titel

Clinical features and outcomes of newly diagnosed follicular lymphoma concurrent with diffuse large B-cell lymphoma component

Ist Teil von

• Zhōnghuá xuèyèxué zázhì, 2022-06, Vol.43 (6), p.456

Ort / Verlag

China

Erscheinungsjahr

2022

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To explore the clinical features and survival of newly diagnosed follicular lymphoma (FL) patients with diffuse large B-cell lymphoma (DLBCL) component. 1845 newly diagnosed FL patients aged ≥ 18 years with grades 1-3a in 11 medical centers in China from 2000 to 2020 were included, and patients with DLBCL component were screened. The clinical data and survival data of the patients were retrospectively analyzed, and the prognostic factors were screened by univariate and multivariate analysis. 146 patients (7.9% ) with newly diagnosed FL had DLBCL component. The median age was 56 (25-83) years, 79 males (54.1% ) . The pathology of 127 patients showed the proportion of DLBCL component. Patients were divided into two groups according to whether the proportion of DLBCL component was ≥ 50% . The study found that patients with DLBCL component ≥ 50% had higher grade 3 ratio (94.3% 91.9% , =0.010) , Ki-67 index ≥ 70% ratio (58.5% 32.9% , =0.013) and PET-CT SUVmax ≥ 13 ratio (72.4% 46.3% , =0.030) than patients with DL