Natural product research, 2023-03, Vol.37 (6), p.928-935
2023
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Details
- Autor(en) / Beteiligte
- Titel
- Anti-inflammatory flavonoid derivatives from the heartwood of Dalbergia odorifera T. Chen
- Ist Teil von
- Natural product research, 2023-03, Vol.37 (6), p.928-935
- Ort / Verlag
- England: Taylor & Francis
- Erscheinungsjahr
- 2023
- Quelle
- Taylor & Francis
- Beschreibungen/Notizen
- Two pairs of flavonoid enantiomers (1a/1b and 2a/2b) together with three known analogues (3-5) were isolated from the heartwood of Dalbergia odorifera T. Chen. Their structures were elucidated by extensive spectroscopic analysis (1 D and 2 D NMR, UV, IR, and HRMS) and experimental and calculated ECD data. Compound 2 features an unusual 2-methyl-3(2H)-furanone moiety forming the C-ring of flavonoid, and its putative biosynthetic pathway is also proposed. Compounds 3‒5 exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC 50 values of 14.7 ± 0.3 μM, 40.2 ± 1.1 μM, and 3.2 ± 0.1 μM, respectively.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1478-6419eISSN: 1478-6427DOI: 10.1080/14786419.2022.2098494Titel-ID: cdi_pubmed_primary_35822397
- Format
- –
- Schlagworte
- Animals, anti-inflammation, Anti-Inflammatory Agents - chemistry, Anti-Inflammatory Agents - pharmacology, Dalbergia - chemistry, Dalbergia odorifera, Dalbergia odorifera T. Chen, Enantiomers, flavonoid derivative, Flavonoids, Flavonoids - chemistry, Flavonoids - pharmacology, GIAO NMR calculation, Inflammation, Lipopolysaccharides, Mice, Nitric oxide, NMR, Nuclear magnetic resonance, Plant Extracts - chemistry, RAW 264.7 Cells