Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Early-onset sepsis in very preterm neonates in Australia and New Zealand, 2007-2018
Ist Teil von
Archives of disease in childhood. Fetal and neonatal edition, 2023-01, Vol.108 (1), p.31
Ort / Verlag
England
Erscheinungsjahr
2023
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
To evaluate the epidemiology and population trends of early-onset sepsis in very preterm neonates admitted to neonatal intensive care units (NICU) in Australia and New Zealand.
Retrospective observational cohort study using a dual-nation registry database.
29 NICUs that have contributed to the Australian and New Zealand Neonatal Network.
Neonates born at <32 weeks' gestation born between 2007 and 2018 and then admitted to a NICU.
Microorganism profiles, incidence, mortality and morbidity.
Over the 12-year period, 614 early-onset sepsis cases from 43 178 very preterm admissions (14.2/1000 admissions) were identified. The trends of early-onset sepsis incidence remained stable, varying between 9.8 and 19.4/1000 admissions (linear trend, p=0.56). The leading causative organisms were
(
) (33.7%) followed by group B
(
) (16.1%). The incidence of
increased between 2007 (3.2/1000 admissions) and 2018 (8.3/1000 admissions; p=0.02). Neonates with
had higher odds of mortality compared with those with
(OR=2.8, 95% CI 1.2 to 6.1). Mortality due to
decreased over the same period (2007: 0.6/1000 admissions, 2018: 0.0/1000 admissions; p=0.01). Early-onset sepsis tripled the odds of mortality (OR=3.0, 95% CI 2.4 to 3.7) and halved the odds of survival without morbidity (OR=0.5, 95% CI 0.4 to 0.6).
Early-onset sepsis remains an important condition among very preterm populations. Furthermore,
is a dominant microorganism of very preterm early-onset sepsis in Australia and New Zealand. Rates of
have been increasing in recent years, while
-associated mortality has decreased.