Details

Autor(en) / Beteiligte

• Lobel, H O
• Roberts, J M
• Somaini, B
• Steffen, R

Titel

Efficacy of malaria prophylaxis in American and Swiss travelers to Kenya

Ist Teil von

• The Journal of infectious diseases, 1987-06, Vol.155 (6), p.1205-1209

Ort / Verlag

United States

Erscheinungsjahr

1987

Quelle

MEDLINE

Beschreibungen/Notizen

• The protective effect of malaria chemoprophylaxis with either Fansidar (pyrimethamine-sulfadoxine) or chloroquine was estimated by determining the attack rates of Plasmodium falciparum infections acquired in Kenya and imported by U.S. and Swiss travelers who had used no chemoprophylaxis, who had used only chloroquine for prophylaxis, and who had used Fansidar weekly, either alone or in combination with chloroquine. The estimated attack rates were almost identical in U.S. and Swiss travelers. The attack rate per 100,000 travelers averaged 280 in those who did not use chemoprophylaxis, 162 in those who took 4-aminoquinolines (P greater than .05), and 27 in those who used Fansidar for prophylaxis (P less than .001). Non-immune travelers to Kenya have an appreciable risk of acquiring a P. falciparum infection and need to be informed of current guidelines for chemoprophylaxis. The changing drug susceptibility patterns in Africa require continuous evaluation of the efficacy of recommended drug regimens for malaria prophylaxis.